Progesterone is a key hormone for fertility, but it is often misunderstood. A common myth is that progesterone only matters during pregnancy. In fact, it regulates the menstrual cycle and prepares the uterine lining for implantation. A deficiency can contribute to cycle irregularities and recurrent miscarriage. However, evidence for routine progesterone supplementation in unexplained infertility is weak. Many women with low progesterone levels still conceive. Progesterone's effect also depends on estrogen balance and individual receptor function. Direct-to-consumer tests often measure only total progesterone, not the free, bioavailable form or receptor sensitivity. Therefore, such results should be interpreted with caution. Another myth is that progesterone cream boosts fertility – controlled trials show no clear benefit. The fact is: progesterone is important but not the sole factor. Comprehensive hormone assessment and medical guidance are recommended.
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