What role does SHBG play in Müdigkeit?

SHBG (sex hormone-binding globulin) modulates the free fraction of testosterone and estradiol. Low SHBG is linked to insulin resistance, metabolic syndrome, and obesity—conditions that often cause fatigue. High SHBG can reduce free androgen availability, also potentially contributing to tiredness. However, SHBG is not a direct fatigue biomarker; evidence is observational and mechanistic. A DNA test for SHBG gene variants may indicate genetic predisposition to SHBG levels, but fatigue is multifactorial (sleep, stress, diet, hormones). Without clinical validation and physician interpretation, such a test should not guide interventions. Safety note: persistent fatigue warrants medical evaluation.