How are CLOCK and longevity related?

The link between CLOCK and longevity is indirect and largely mechanistic. CLOCK is a core circadian gene regulating metabolism, inflammation, and cellular repair. Circadian disruption (e.g., shift work, poor sleep) is associated in epidemiological studies with increased risk of cardiovascular disease, diabetes, and earlier mortality. Animal models show that CLOCK mutations can accelerate aging. In humans, single SNPs like rs1801260 are linked to small differences in sleep duration, but effects on lifespan are minimal and polygenic. Evidence for direct longevity prediction from CLOCK variants is weak – no robust GWAS links a single CLOCK SNP to extended lifespan. Consumer DNA tests often overstate clinical relevance. Lifestyle factors (regular sleep, light exposure, stress management) are far more impactful. Safety note: Do not base clinical decisions solely on CLOCK genetics.