What role does Zöliakie Test play in Müdigkeit?

A celiac test (e.g., HLA-DQ genotyping or tTG-IgA antibodies) can be relevant for fatigue if undiagnosed celiac disease is present. Celiac disease frequently causes chronic exhaustion due to malabsorption, inflammation, or associated conditions like anemia. A genetic test (HLA-DQ2/DQ8) only indicates predisposition – about 30 % of the population carry risk alleles, but only a fraction develop the disease. A positive genetic test alone does not explain fatigue. Diagnosis requires serological confirmation (tTG-IgA) and possibly duodenal biopsy. Without clinical workup, a genetic test may create false reassurance or unnecessary worry. For persistent fatigue, always consult a physician who can interpret results in context. Evidence is mixed: strong for the celiac–fatigue link, but weak for the predictive value of a standalone genetic test.