Can tTG IgA help with Langlebigkeit?

The question of whether tTG IgA (tissue transglutaminase IgA) can help with longevity is indirect. tTG IgA is a well-established biomarker for celiac disease, an autoimmune condition that, if untreated, can cause chronic inflammation, nutrient malabsorption, and increased risk for osteoporosis, anemia, and other comorbidities. Early diagnosis and a gluten-free diet can mitigate these risks, potentially improving quality of life and lifespan. However, tTG IgA is not a direct longevity marker for the general population. Evidence for benefit in asymptomatic individuals without celiac risk is weak. Longevity is multifactorial—influenced by genetics, diet, exercise, stress, sleep, and biomarkers like HbA1c, CRP, or lipids. A tTG IgA test is only indicated when celiac disease is clinically suspected. For a general longevity strategy, broader assessments (e.g., microbiome, nutrient status, inflammatory markers) are more relevant. Caveat: false positives occur; a positive test should be confirmed by duodenal biopsy.