Myths vs facts: MTHFR and Allergie

MTHFR (methylenetetrahydrofolate reductase) is an enzyme involved in folate metabolism. Variants like C677T (rs1801133) can reduce enzyme activity and raise homocysteine levels. Online claims often link MTHFR to allergies, but the scientific evidence is weak to moderate. Some studies report associations between MTHFR polymorphisms and elevated IgE or allergic conditions, but effect sizes are small and findings inconsistent. Allergies are multifactorial (environment, diet, microbiome, other genes). A direct causal link is not established. DTC tests like MyBody-X can detect MTHFR variants, but results are not diagnostic for allergies. Supplementation with methylfolate should only be done under medical guidance, as high doses may have adverse effects. Bottom line: MTHFR is one of many risk factors, not an allergy test.