MyBody-X angle on MTHFR Männer

MTHFR genetics in men is often linked to homocysteine metabolism and cardiovascular risk. Variants such as C677T (rs1801133) and A1298C (rs1801131) can reduce enzyme activity, potentially leading to elevated homocysteine levels. Studies show a moderate association between high homocysteine and cardiovascular disease, but evidence for a causal role of single MTHFR variants is limited. Randomized controlled trials with folic acid supplementation have not demonstrated clear benefit for primary prevention. Men with MTHFR variants may have increased folate and vitamin B12 needs, but routine supplementation is not recommended. MyBody-X tests can detect these variants, but results should not be taken as medical diagnosis or prescription. The evidence is mostly observational (human-moderate). Safety note: High-dose folic acid can mask vitamin B12 deficiency. Individual medical advice is advised.