Is VDR useful for Haut?

The question of whether VDR (Vitamin D receptor) is useful for skin health cannot be directly answered from the provided context, as it contains no specific information on VDR and skin. From a scientific perspective: VDR is expressed in keratinocytes, fibroblasts, and hair follicle cells, and it regulates skin barrier function, cell proliferation, and immune modulation. Mutations in the VDR gene cause hereditary vitamin D-resistant rickets with alopecia, highlighting its role in hair cycling. For general skin conditions (e.g., acne, psoriasis, aging), evidence comes from observational and mechanistic studies, but there are no robust clinical guidelines recommending VDR genotyping for healthy individuals. Consumer DNA tests that include VDR variants often overclaim clinical utility. The evidence is primarily mechanistic and observational, not sufficient for preventive or therapeutic decisions. A serum vitamin D level is more clinically actionable than a VDR genotype. Thus, while VDR is biologically relevant for skin, its usefulness as a consumer test marker is limited and not evidence-based for routine skin optimization.