TSH (thyroid-stimulating hormone) measurement is a well-established screening tool for thyroid dysfunction. Hypothyroidism commonly presents with fatigue, lethargy, and weight gain. However, fatigue is a highly nonspecific symptom with many potential causes (iron deficiency, sleep disorders, stress, infections, etc.). A single TSH value, as offered in the MyBody-X Menopause Check, can provide a clue but cannot replace a clinical diagnosis. The evidence for TSH utility in fatigue is strong (standard medical practice), but interpretation requires context. If TSH is abnormal or fatigue persists, a full thyroid panel (fT3, fT4, antibodies) and medical evaluation are needed. Limitations include diurnal variation and medication interference. Overall, TSH is a useful initial biomarker for fatigue, but not definitive on its own.
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