What to watch with MTHFR and Fruchtbarkeit?

MTHFR variants (C677T, A1298C) are often linked to fertility concerns, but the evidence is moderate. Some studies suggest associations with recurrent pregnancy loss or elevated homocysteine affecting implantation. However, most carriers have normal fertility. Effects are small and not deterministic. Important: a genetic test alone does not predict actual fertility – lifestyle, age, hormonal status, and clinical factors dominate. Methylfolate supplementation is not universally recommended unless deficiency is confirmed or under medical guidance. In Germany, such tests fall under GenDG; physician involvement is advised. Beware of exaggerated marketing claims.