The so-called weight loss injection (GLP-1 receptor agonists like semaglutide) is an effective medication for weight reduction, but it carries clear risks and limitations. Common side effects include nausea, vomiting, diarrhea, and constipation, often leading to discontinuation. A major risk is loss of muscle mass, which can be mitigated by concurrent resistance training. Without adequate protein intake and exercise, weight loss may come at the expense of muscle health, lowering basal metabolic rate and promoting future weight regain. Long-term effects on cardiovascular and metabolic health are not fully understood; most trials last up to two years. The injection is not a substitute for sustainable dietary changes and physical activity – it works only as long as it is taken. After discontinuation, weight regain is common. Costs are high and not always covered by insurance. The evidence is mixed: strong efficacy in clinical trials, but many open questions about long-term safety and optimal training integration. Medical supervision is mandatory.
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