Evidence check: HLA-DQ2 in the context of sleep

There is no established evidence linking HLA-DQ2 directly to sleep. HLA-DQ2 is a well-known genetic marker for celiac disease. In untreated celiac disease, sleep disturbances can occur due to systemic inflammation or nutrient deficiencies (e.g., iron, vitamin D) – but this is an indirect consequence of the disease, not a direct effect of the gene on sleep regulation. Consumer DNA tests often include markers with weak or speculative associations to sleep. Unless celiac disease is present, HLA-DQ2 has no known relevance for sleep quality or duration. The evidence is unclear: no human studies directly associate HLA-DQ2 with sleep parameters. Be cautious of overinterpreted genetic test results – many reported associations are statistically weak or not replicated.