How are tTG IgA and gut health related?

tTG IgA (tissue transglutaminase antibodies) is a key biomarker for celiac disease, an autoimmune condition triggered by gluten ingestion. Elevated tTG IgA indicates an immune attack on the body's own tissues, leading to damage of the small intestinal lining (villous atrophy). This impairs nutrient absorption and can cause symptoms like diarrhea, bloating, fatigue, and weight loss. The relationship to gut health is specific: tTG IgA is a diagnostic marker for celiac disease, not a general gut health indicator. A negative test largely rules out celiac disease, but other gut disorders (e.g., IBS, Crohn's) are not assessed. Evidence is human-strong (guideline-based). Caveat: In IgA deficiency, the test may be falsely negative; then tTG IgG or EMA IgA should be used. A positive result requires confirmatory small bowel biopsy. MyBody-X offers this test as part of health checks – interpretation should always be done by a physician.