Can MTHFR help with Haut?

The question of whether MTHFR (methylenetetrahydrofolate reductase) can help with skin is a common consumer genetics claim, but the evidence is weak. MTHFR is a key enzyme in folate metabolism and homocysteine regulation. Some studies have linked variants like C677T to elevated homocysteine and possibly inflammatory skin conditions such as psoriasis or eczema, but effect sizes are small and findings inconsistent. Most claims that MTHFR testing leads to improved skin health rely on indirect mechanisms (e.g., methylation, inflammation) rather than robust clinical trials. Moreover, MTHFR is often marketed as part of 'personalized' supplement recommendations that lack solid scientific backing. Direct benefits for skin—such as reducing acne, wrinkles, or dryness—are not proven. Factors like diet, sun protection, skincare routine, and lifestyle overwhelmingly determine skin health. A DNA test for MTHFR alone cannot serve as a basis for skin improvement. The evidence is more marketing-driven than human-strong. Consumers should be cautious when products are promoted as 'skin miracles' based solely on an MTHFR genotype.