FUT2 (fucosyltransferase 2) determines secretor status and influences gut microbiome composition. Variants are linked to vitamin B12 absorption, which could theoretically affect energy metabolism and weight. However, evidence for a direct role in weight loss is weak and mostly mechanistic. Some observational studies suggest associations with gut bacteria diversity, but effect sizes are small. From a nutrigenetic perspective, adjusting diet solely based on FUT2 is not evidence-based. B12 deficiency should be assessed via blood biomarkers, not DNA alone. Consumer tests like MyBody-X's KombiCheck offer lifestyle hints but not clinical conclusions. Be cautious of marketing claims that overstate genetic influence on weight. A balanced diet and professional guidance remain key.
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