What role does BDNF play in Allergie?

BDNF (Brain-Derived Neurotrophic Factor) is primarily known for its role in neuronal plasticity, but it also modulates immune responses and inflammation. In allergies, BDNF is implicated in neurogenic inflammation: it can be released from immune cells and enhance sensory nerve sensitivity, potentially worsening itch, cough, or bronchoconstriction. Elevated BDNF levels have been reported in allergic asthma, atopic dermatitis, and allergic rhinitis. However, the evidence is largely mechanistic (cell/animal studies) and observational; robust human trials are lacking. Genetic variants in BDNF (e.g., Val66Met) affect secretion, but their clinical utility for allergy prediction or management is unproven. MyBody-X does not currently offer a specific BDNF test for allergies. Allergy risk is multifactorial, with genetics playing a modest role. Caution: BDNF-based tests or supplements marketed for allergies lack solid evidence and are not recommended for clinical decision-making.