What role does VKORC1 play in fatigue?

VKORC1 encodes a key enzyme in the vitamin K cycle and is primarily studied for its role in warfarin sensitivity. There is no strong scientific evidence directly linking VKORC1 variants to fatigue. While vitamin K deficiency could theoretically contribute to low energy through impaired blood clotting or bone metabolism, this is not a validated clinical effect of common VKORC1 polymorphisms. Most claims about VKORC1 and fatigue appear in direct-to-consumer genetic reports without robust backing. The evidence level is unclear; consumers should interpret such associations with caution.