Can SHBG help with longevity?

Whether SHBG (sex hormone-binding globulin) can directly promote longevity is not well established. Higher SHBG levels are associated with lower risk of type 2 diabetes and better metabolic health, which may indirectly support a longer lifespan. However, the evidence is primarily observational and mechanistic; no robust clinical trials show that raising SHBG extends life. SHBG is influenced by insulin resistance, liver function, and lifestyle factors like diet and exercise. Some supplements claim to increase SHBG, but their long-term effects on healthspan are unproven and could disrupt hormonal balance. Moreover, SHBG is a biomarker, not a therapeutic target. For longevity, focusing on proven interventions—caloric restriction, physical activity, metabolic control—is more reliable than trying to manipulate SHBG. Consumer tests offering SHBG as a longevity indicator should be interpreted with caution. Evidence level: mixed, with moderate epidemiological support but lacking causal human data.