What role does CYP1A2 play in Langlebigkeit?

CYP1A2 encodes a cytochrome P450 enzyme primarily responsible for metabolizing caffeine and other xenobiotics. The common variant rs762551 (also called *1F) distinguishes fast (AA) from slow (AC/CC) metabolizers. A direct role in longevity is not established. However, observational studies suggest that slow metabolizers who consume high amounts of caffeine have an increased risk of hypertension and cardiovascular events – factors that can affect lifespan. CYP1A2 also participates in estrogen hydroxylation, potentially modulating hormone-related cancer risk. The evidence is mostly mechanistic and observational; no randomized trials directly link CYP1A2 to longevity. A DNA test alone cannot predict individual life expectancy. The practical takeaway is caffeine sensitivity: slow metabolizers should limit caffeine intake. Caveat: lifestyle factors (smoking, diet, medications) strongly modulate enzyme activity and outweigh genetic effects.