CRP (C-reactive protein) is a non-specific marker of inflammation. Common causes of elevated CRP include acute infections (viral or bacterial), chronic inflammatory diseases (e.g., rheumatoid arthritis), tissue damage (surgery, injury), and lifestyle factors such as smoking, obesity, and metabolic syndrome. Mild elevations (1–10 mg/L) can also result from subclinical inflammation or stress. The CRP rs1205 genetic variant influences baseline CRP production, but the effect is small and not clinically actionable on its own. Important: CRP alone is not diagnostic; it must be interpreted in clinical context. Persistently elevated CRP warrants medical evaluation, especially to rule out cardiovascular risk or chronic inflammation. Evidence for the clinical utility of CRP is strong (human-strong), but the genetic component is moderate and not deterministic.
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