Myths vs facts: BDNF and Allergie

BDNF (Brain-Derived Neurotrophic Factor) is primarily known for its role in neuronal growth and plasticity. In allergy research, BDNF has emerged as a mediator of neurogenic inflammation – it is released by immune cells such as mast cells and eosinophils and can enhance nerve fiber sensitivity in airways and skin. Studies have found elevated BDNF levels in asthma, allergic rhinitis, and atopic dermatitis. However, the claim that a genetic test for BDNF polymorphisms (e.g., Val66Met) can predict individual allergy risk or guide treatment is not evidence-based. Effect sizes are small, results are inconsistent, and environmental factors dominate. There is no validated clinical utility for BDNF genotyping in allergy management. Fact: BDNF is a promising research biomarker for allergic inflammation. Myth: A DNA test for BDNF can personalize your allergy therapy.