What to watch with tTG IgA and fertility?

tTG IgA (tissue transglutaminase antibodies) is a serological marker for celiac disease. Untreated celiac disease can impair fertility through malabsorption of key nutrients (iron, folate, vitamin D) and chronic inflammation. If you are planning pregnancy or already pregnant, an elevated tTG IgA level warrants attention – a strict gluten-free diet is the only proven treatment. Antibody levels typically normalize within 6–12 months on the diet, which can improve fertility outcomes. Important: tTG IgA is an antibody test, not a genetic test. A positive result should be confirmed by duodenal biopsy. The evidence linking celiac disease to fertility issues is human-strong (meta-analyses), but the provided context lacks specific studies on this topic. Therefore, if you have elevated tTG IgA and are trying to conceive, consult a gastroenterologist and a dietitian. Do not self-prescribe supplements without medical supervision.