What role does Zink play in Langlebigkeit?

Zinc is an essential trace element involved in numerous cellular processes relevant to longevity, including DNA repair, antioxidant defense (as a cofactor for superoxide dismutase), immune function, and telomere maintenance. Observational studies link adequate zinc status to lower inflammatory markers and slower age-related decline. However, evidence for a direct lifespan-extending effect in humans is limited: randomized controlled trials of zinc supplementation do not consistently show increased lifespan in healthy adults. Moreover, excessive intake (e.g., >40 mg/day) can be toxic and induce copper deficiency. Zinc's role in longevity is best viewed as supportive for healthy aging rather than a magic bullet. Genetic variants in the zinc transporter gene SLC30A8 (e.g., rs13266634) affect zinc metabolism and are associated with diabetes risk – an indirect link to life expectancy. Overall, the evidence is human-moderate: mechanistic and observational studies support its importance, but robust interventional data for extending maximum lifespan are lacking.