Progesterone plays a significant role in sleep regulation, especially in women. It acts on GABA-A receptors, promoting sleep onset and improving sleep quality. During the menstrual cycle, progesterone rises in the luteal phase, often associated with deeper sleep. In pregnancy, high progesterone levels contribute to increased drowsiness. Hormone replacement therapy using progesterone can alleviate sleep disturbances during menopause. Evidence comes from observational and clinical studies, but effects vary individually. Important: Progesterone is not an over-the-counter sleep aid; use should be under medical supervision due to potential side effects like dizziness or mood changes. Its role in men is less studied. Overall, the link between progesterone and sleep is well-supported, though not uniform across all individuals.
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