What role does ADH1B play in Langlebigkeit?

ADH1B encodes alcohol dehydrogenase, which metabolizes ethanol to acetaldehyde. The fast-metabolizing variant (rs1229984) leads to acetaldehyde accumulation, associated with reduced alcohol intake and lower risk of alcohol-related cancers. This could theoretically increase lifespan, but direct evidence from the provided context is lacking. The association is mechanistically plausible but not supported by longevity studies in the given material. Caveat: the effect is indirect and confounded by lifestyle factors.