What role does VKORC1 play in Fruchtbarkeit?

VKORC1 encodes a key enzyme for vitamin K recycling, essential for blood clotting and bone metabolism. There is no established direct role for VKORC1 in human fertility. Common variants (e.g., rs9923231) primarily affect warfarin sensitivity. In pregnancy, inadequate vitamin K activity could theoretically impair placental function or embryonic development, but robust clinical evidence linking VKORC1 to infertility is lacking. Evidence is therefore unclear/mechanistic. Genetic testing for VKORC1 is not recommended in routine fertility workup. If coagulation issues or recurrent pregnancy loss are present, a physician may consider broader testing, but not based solely on this gene.