Progesterone is often surrounded by myths during menopause. Fact: Progesterone is a key hormone produced in the second half of the menstrual cycle, preparing the uterine lining. During menopause, progesterone levels decline, contributing to irregular cycles, hot flashes, and sleep disturbances. A common myth is that progesterone alone can relieve all menopausal symptoms – in reality, it is usually combined with estrogen in hormone replacement therapy to protect the endometrium. Another myth: progesterone is dangerous. The truth is that hormone therapy has both benefits and risks that must be assessed individually. The claim that 'natural' progesterone is always superior to synthetic is not strongly supported by evidence. Overall evidence is human-strong for basic physiology and therapy effects, but many nuances remain. Caveat: self-medication with progesterone creams or supplements without medical supervision is not recommended, as dosing and safety are complex.
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