What do studies say about MTHFR Genetik?

MTHFR genetics, especially C677T and A1298C variants, are commonly marketed in direct-to-consumer tests for 'precision medicine.' Studies show a clear association with elevated homocysteine levels, particularly in TT homozygotes. However, evidence for downstream health risks (cardiovascular, thrombosis) is moderate to conflicting. Randomized controlled trials do not support routine personalized folate supplementation based on MTHFR status in the general population. Clinical utility is therefore limited. Many consumer tests overstate implications. A balanced diet with adequate folate is recommended for everyone, regardless of genotype.