How are CYP2D6 and longevity related?

The relationship between CYP2D6 and longevity is not clearly established in the scientific literature. CYP2D6 is a key drug-metabolizing enzyme responsible for processing about 20–25% of common medications. Some studies have explored associations between CYP2D6 variants and lifespan, but results are inconsistent and often based on small cohorts or indirect effects. For example, altered enzyme activity may influence drug efficacy and side effects in older adults, potentially affecting health outcomes. However, no robust GWAS or interventional studies demonstrate a direct causal link between CYP2D6 polymorphisms and extended lifespan. The evidence is best described as unclear or mechanistic-speculative. A CYP2D6 DNA test can be useful for pharmacogenetic guidance, but not for predicting longevity. MyBody-X tests are screening tools, not diagnostic. Always consult a physician regarding medication adjustments.