What role does FT4 play in Wechseljahre?

The role of free T4 (FT4) during menopause is a valid scientific question, but the provided context lacks direct data or studies on this topic. FT4 is the active thyroid hormone regulating metabolism. During menopause, estrogen declines, which can indirectly affect thyroid function – for example, through changes in thyroxine-binding globulin (TBG). Some women develop subclinical hypothyroidism during this phase, potentially contributing to fatigue, weight gain, and mood swings. However, the link is not clear-cut: menopause itself does not cause thyroid dysfunction, but pre-existing issues may become more apparent. An FT4 test alone is insufficient; TSH and fT3 should also be measured. DNA tests for thyroid-related genes (e.g., DIO2, TSHR) have small effect sizes and cannot replace blood biomarkers. The evidence here is unclear because the context provides no specific support. Be cautious of marketing claims. If symptoms arise, consult an endocrinologist.