Magnesium and gut health are closely linked. Magnesium supplements, especially citrate or oxide forms, can cause diarrhea due to their osmotic effect, particularly at doses above 350 mg/day. This may disrupt the gut microbiome and lead to electrolyte imbalances. Conversely, magnesium supports bowel muscle function and can relieve constipation. Individuals with sensitive guts (e.g., IBS) should prefer well-tolerated forms like magnesium glycinate or bisglycinate. Evidence is mostly mechanistic; no strong clinical trials exist for optimal combination strategies. Caution is advised when taking medications or if kidney function is impaired. A magnesium status test (e.g., RBC magnesium) may help before high-dose supplementation.
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