Myths vs facts: IgE and Müdigkeit

Myth: High IgE directly causes fatigue. Fact: IgE is an antibody involved in allergic reactions and parasite defense. Chronic allergic inflammation (e.g., allergic rhinitis, asthma) can lead to fatigue via sleep disruption, medication side effects, or systemic immune activation. However, many individuals with elevated IgE are asymptomatic, and fatigue is multifactorial (e.g., iron deficiency, thyroid dysfunction, depression). An isolated high IgE without clinical allergy does not explain tiredness. Evidence: human-moderate (observational studies). Caveat: No proven causal link; clinical evaluation for other causes is warranted.