Can VKORC1 help with Müdigkeit?

VKORC1 encodes vitamin K epoxide reductase, a key enzyme in the vitamin K cycle that regulates blood coagulation and bone metabolism. There is no robust scientific evidence directly linking VKORC1 variants to fatigue („Müdigkeit“). In clinical practice, VKORC1 testing is used primarily for warfarin dosing, not for fatigue assessment. While severe vitamin K deficiency or rare VKORC1 mutations could theoretically cause bleeding or bone issues that might contribute to tiredness, this is not supported by controlled studies. Consumer DNA tests that market VKORC1 as a 'fatigue gene' overstate the evidence. For persistent fatigue, standard workups (iron, thyroid, sleep, mental health) are far more relevant. The evidence for VKORC1 directly influencing fatigue is unclear.