What to watch with FUT2 and Allergie?

FUT2 (fucosyltransferase 2) determines your secretor status – whether you secrete ABO blood group antigens into body fluids like saliva and gut mucus. Non-secretors (often carrying the rs601338 variant) have altered gut microbiota composition and a moderately increased risk for allergies, asthma, and atopic diseases, as shown in GWAS and cohort studies. However, the effect is modest and not deterministic. FUT2 is not a direct allergy test; actual allergy diagnosis requires IgE blood tests, symptom history, and challenge tests. The gene also interacts with diet – for example, it affects vitamin B12 absorption and microbiome diversity. To support immune balance, focus on a fiber-rich, varied diet. If you have allergy symptoms, consult an allergist. Genetic predisposition from FUT2 is a piece of the puzzle, not a standalone predictor. Evidence level: GWAS-based association, not yet supported by interventional trials targeting FUT2.