How are FTO and Langlebigkeit related?

The relationship between the FTO gene and longevity is indirect, primarily mediated through body fat regulation. FTO variants (e.g., rs9939609) are among the most robustly replicated genetic risk factors for obesity. Higher BMI is associated with increased risk of cardiovascular disease, type 2 diabetes, and certain cancers, which can shorten lifespan. However, several studies show that the direct effect of FTO on mortality disappears after adjusting for BMI – the gene itself is not a 'longevity gene'. Some research suggests potential protective effects in specific populations (e.g., lower Alzheimer's risk), but these findings are not consistently replicated. Evidence is moderate, based on GWAS and epidemiological data. Importantly, a consumer DNA test for FTO cannot predict individual lifespan; lifestyle factors like diet, exercise, and environment are far more influential. MyBody-X DNA tests can indicate obesity risk but not longevity. Always consult a healthcare professional for personalized advice.