Evidence check: SHBG in the context of weight loss

SHBG (sex hormone-binding globulin) is a carrier protein for sex steroids and a key marker of hormonal and glucose metabolism. In the context of weight loss, SHBG typically increases because caloric restriction and improved insulin sensitivity enhance hepatic SHBG production. Low SHBG levels are associated with insulin resistance, metabolic syndrome, and fatty liver. Studies indicate that a 5–10% weight reduction can significantly raise SHBG, reflecting improved metabolic health. However, SHBG is not a direct predictor of weight loss but rather a concomitant marker. Evidence is based on human observational and interventional studies (human-moderate). Limitations: SHBG is also influenced by estrogens, thyroid function, and liver disease. An isolated SHBG value without additional hormone and metabolic parameters has limited utility. MyBody-X measures SHBG as part of hormone panels; interpretation should always be in a clinical context. Safety note: Do not initiate supplementation or hormone therapy based solely on an SHBG result without medical evaluation.