Myths vs facts: tTG IgA and blood sugar

tTG IgA (tissue transglutaminase IgA) is a specific biomarker for celiac disease, an autoimmune condition triggered by gluten. A positive test indicates possible celiac disease, not directly blood sugar issues. However, untreated celiac disease can cause malabsorption, which may lead to blood glucose fluctuations, especially in individuals with diabetes. It is a myth that tTG IgA levels directly measure or predict blood sugar. Blood sugar is assessed via HbA1c, fasting glucose, or CGM. Elevated tTG IgA should always be evaluated by a gastroenterologist before making dietary changes. Caveat: A positive test does not confirm celiac disease without biopsy. For blood sugar concerns, separate diabetes tests are needed. The evidence for a direct link between tTG IgA and blood sugar is weak and based on indirect observations.