When should SHBG be retested?

The timing for retesting SHBG (sex hormone-binding globulin) depends on the clinical context. SHBG is commonly measured when evaluating hyperandrogenism (e.g., PCOS), thyroid disorders, liver disease, or when using medications that alter SHBG levels (oral contraceptives, antiepileptics, glucocorticoids). Retesting is indicated after significant changes in the underlying condition or therapy, such as weight loss, initiation of metformin, or stabilization of thyroid function. In asymptomatic individuals without risk factors, routine retesting is not evidence-based. The half-life of SHBG is about 7 days, so follow-up should be at least 2–4 weeks after a change. Evidence for specific retesting intervals is weak; current practice relies on clinical guidelines for the associated condition. Note: SHBG has diurnal variation (highest in the morning) and should be measured fasting. The provided context contained no direct information on SHBG retesting; this answer is based on general clinical practice.