Is ApoB useful for fertility?

ApoB (Apolipoprotein B) is a core component of LDL and other atherogenic lipoproteins. Some evidence links elevated ApoB levels to fertility issues, particularly in women with PCOS (polycystic ovary syndrome) and men with impaired sperm quality. However, the evidence is moderate, mostly from observational and mechanistic studies. ApoB is not a standard fertility marker; clinical parameters like hormone profiles, AMH, or semen analysis are more relevant. Elevated ApoB may indicate cardiovascular risk, which could indirectly affect fertility. Caveat: interpreting ApoB in isolation is difficult; it should be assessed alongside a full lipid panel and clinical context. Consumer DNA tests for ApoB-related variants have limited predictive value. Current evidence does not support routine ApoB testing for fertility assessment.