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What to watch with tTG IgA and Haut?

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What to watch with tTG IgA and Haut?

tTG IgA is the primary serological marker for celiac disease. When considering skin issues, the key condition is dermatitis herpetiformis (DH), an intensely itchy, blistering skin disorder that is the cutaneous manifestation of celiac disease. Elevated tTG IgA supports DH diagnosis, but definitive diagnosis requires skin biopsy with direct immunofluorescence showing granular IgA deposits. Other skin conditions like psoriasis, alopecia areata, or chronic urticaria have been associated with gluten sensitivity, but evidence is weaker. Caveat: tTG IgA can be falsely elevated in liver disease, infections, or other autoimmune conditions. A positive test alone does not justify a gluten-free diet; confirm with EMA IgA and/or duodenal biopsy. Even without GI symptoms, skin issues may warrant celiac screening. Evidence: human-strong for DH-celiac link. Sources: none in context.

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