What to watch with BDNF and Wechseljahre?

BDNF (Brain-Derived Neurotrophic Factor) is a key protein for neuroplasticity—the brain's ability to adapt and form new connections. During menopause, estrogen levels drop, and estrogen regulates BDNF expression. A decline in BDNF has been linked to cognitive decline, mood swings, and increased risk for neurodegenerative diseases. However, the evidence is not uniform: some women show no measurable BDNF changes, and individual genetics (e.g., the BDNF Val66Met polymorphism) modulate baseline BDNF activity. Consumer DNA tests alone cannot provide a personalized statement about BDNF status during menopause. It is more useful to focus on lifestyle factors that are proven to support BDNF: regular aerobic exercise, adequate sleep, omega-3 fatty acids, and cognitive stimulation. Hormone replacement therapy may stabilize BDNF levels in some women but should be evaluated individually with a doctor. Be cautious of exaggerated claims from supplements that supposedly boost BDNF—the evidence is often weak. In summary, BDNF is an interesting biomarker but not an isolated 'game changer' in menopause. Holistic measures are currently best supported by evidence.