What role does SHBG play in Langlebigkeit?

SHBG (sex hormone-binding globulin) modulates the bioavailability of testosterone and estradiol. Higher SHBG is consistently associated with better metabolic health, lower diabetes risk, and reduced cardiovascular mortality – all linked to longevity. However, causality remains uncertain; SHBG rises with age while sex hormones decline. The provided context lacks direct SHBG studies; evidence is observational and mechanistic. Genetic variants (e.g., in the SHBG gene) have small effects. Conclusion: SHBG is a biomarker, not a direct longevity driver. Lifestyle interventions (weight loss, Mediterranean diet) can raise SHBG, but individual levels should be interpreted by a physician. No actionable genetic test exists for SHBG-based longevity.