What role does SHBG play in skin aging?

SHBG (sex hormone-binding globulin) modulates the bioavailability of testosterone and estrogen. Lower SHBG levels can increase free androgens, which are linked to acne, seborrhea, and accelerated skin aging. Estrogen, conversely, supports collagen synthesis and skin elasticity. However, the provided context contains no direct evidence linking SHBG to skin aging. The association is based on mechanistic reasoning and indirect hormone studies. Genetic variants in SHBG (e.g., rs1799941) affect SHBG concentrations, but their impact on skin aging is small and not clinically validated. Conclusion: SHBG likely plays a role in skin aging via hormone regulation, but evidence is limited. Lifestyle factors (sun protection, diet) are far more influential.