HsCRP (high-sensitivity C-reactive protein) is a well-established marker of systemic inflammation. Chronically mildly elevated levels (1–3 mg/L) are associated in large cohorts with increased all-cause mortality and cardiovascular events – both relevant to longevity. However, hsCRP is not a direct longevity test but a risk indicator. Its predictive value is limited because many factors (infections, smoking, obesity) influence hsCRP. For individual longevity assessment, hsCRP is useful but insufficient; it should be interpreted alongside other markers (e.g., lipids, glucose, blood pressure) and lifestyle factors. Consumer tests often include hsCRP, but without clinical context the value can be misleading. Evidence: strong human observational studies for prediction, but no randomized trials showing that hsCRP-guided interventions extend lifespan. Conclusion: Useful as part of a panel, not as a standalone longevity marker.
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