Is VKORC1 useful for longevity?

VKORC1 encodes vitamin K epoxide reductase, a key enzyme for recycling vitamin K. This vitamin is crucial for activating proteins involved in blood clotting and calcium regulation in bones and blood vessels. Some studies have linked VKORC1 variants to bone density or arterial calcification risk—factors that can influence healthy lifespan. However, direct evidence connecting VKORC1 to longevity is weak. Most data come from pharmacogenetic studies on warfarin, not from longevity cohorts. Effect sizes are small and findings inconsistent. Without robust longevity-specific research, the utility of VKORC1 testing for lifespan prediction remains limited. A genetic test alone is insufficient; clinical markers like vitamin K status and vascular health are more informative.