How are MTHFR and longevity related?

The relationship between MTHFR variants and longevity is not clearly established in the scientific literature. MTHFR encodes an enzyme in folate metabolism; the common C677T variant (rs1801133) leads to elevated homocysteine levels, a risk factor for cardiovascular disease. Some studies suggest a link to accelerated aging or cardiovascular mortality, but effect sizes are small and findings inconsistent. Longevity is influenced by many genes, lifestyle, and environment – a single MTHFR SNP has no meaningful predictive power. The evidence is 'mixed': there are mechanistic hints (homocysteine as oxidative stressor) but no robust clinical guidelines. Consumers should not rely on MTHFR testing alone to make claims about their life expectancy. A healthy lifestyle with adequate folate intake (e.g., from leafy greens) is recommended for everyone, regardless of genotype. MyBody-X tests are for lifestyle optimization, not medical diagnosis.