Can COMT help with fatigue?

Whether COMT can help with fatigue is not well-supported by evidence. COMT (catechol-O-methyltransferase) breaks down dopamine and norepinephrine. Certain variants (e.g., rs4680, Val158Met) are linked to altered enzyme activity; slower variants might theoretically increase dopamine levels and energy. However, evidence is weak: no robust clinical trials show a direct causal effect on fatigue. Most data come from small association studies or mechanistic reasoning. Consumer DNA tests like MyBody-X may report COMT variants, but results are not diagnostic and should not guide supplementation or lifestyle changes. Fatigue has many causes (sleep, nutrition, stress, medical conditions) that far outweigh any single gene. Without strong clinical evidence, claims that COMT helps with fatigue remain in the marketing/speculative realm. Persistent fatigue warrants medical evaluation.