How are tTG IgA and weight loss related?

tTG IgA (tissue transglutaminase antibodies) is a primary serological marker for celiac disease, an autoimmune condition triggered by gluten. Weight loss can occur in active celiac disease due to malabsorption, but many patients are normal weight or overweight at diagnosis. The relationship is indirect: untreated celiac disease damages the intestinal lining, impairing nutrient absorption, which may lead to weight loss. However, weight loss is neither sensitive nor specific for celiac disease. The context provided does not mention tTG IgA testing; MyBody-X appears to focus on DNA tests, not antibody tests. tTG IgA is measured via blood draw in clinical labs. Evidence for the link is human-strong (guidelines, systematic reviews). Caveat: do not self-diagnose celiac disease based on weight loss alone; consult a gastroenterologist for proper testing and interpretation.