Is MC4R useful for Abnehmen?

MC4R (melanocortin 4 receptor) is a key regulator of energy balance and appetite. Loss-of-function mutations in this gene are the most common monogenic cause of severe obesity, but these are rare in the general population. Common variants (polymorphisms) in MC4R are associated with a slightly increased BMI, but the effect size is small (about 1–2 kg) and easily overshadowed by lifestyle and environment. For weight loss, a consumer DNA test for MC4R variants has limited practical utility. It cannot provide personalized diet or exercise recommendations beyond general advice. The evidence for the genetic association is moderate, but the clinical actionability is weak. Many companies overstate the importance of such tests. Caveat: a positive result should not lead to fatalism – lifestyle interventions work regardless of genotype.