Can FADS1 help with Langlebigkeit?

FADS1 encodes a delta-5 desaturase involved in converting omega-3 and omega-6 fatty acids. Variants in FADS1 are associated with altered EPA/DHA levels, inflammatory markers, and cardiovascular risk – factors that may influence longevity. However, direct evidence linking FADS1 to human lifespan is lacking. The evidence is primarily mechanistic and based on GWAS for lipid traits. Effect sizes are small, and dietary intake (e.g., fish oil) can modify the genetic impact. For longevity, established modifiable factors (diet, exercise, metabolic health) are far more important. A DNA test can offer insights into fatty acid metabolism but should not be overinterpreted. No clinical trials have tested FADS1-guided interventions for longevity. Evidence grade: mechanistic/unclear.